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Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
drug eruptions, paraneoplastic ... Urticarial/LCV) - Cryoglobulinemic ... Disease • Cogan syndrome ... #skin #dermatology ... #rheumatology #
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of ... - Takayasu arteritis ... - systemic lupus ... dermatomyositis #Size #Classification ... #Diagnosis #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
arthralgia, and arthritis ... (e.g. systemic lupus ... SLE), rheumatoid arthritis ... diagnosis #types #classification ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
ANCA +MPO) • Cryoglobulinemic ... inflammation Others: • Lupus ... such as systemic lupus ... differential #diagnosis #rheumatology ... #classification
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Antiphospholipid-antibody syndrome ... • Vasculitis ... lesions • Discoid lupus ... Sarcoidosis #dermatology ... differential #diagnosis #rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome ... • Giant cell arteritis ... rash #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... ANCA-associated vasculitis ... Non-autoimmune rheumatologic ... • Mesenteric vasculitis ... Erythematosus #Diagnosis #Rheumatology
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
of the joints (arthritis ... Leukocytoclastic vasculitis ... - Lupus - Leukemia ... Treatment: - Systemic ... #diagnosis #dermatology
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
) • Cutaneous vasculitis ... : • 7%, Cryoglobulinemia ... Arthralgia and Arthritis ... Adenocarcinoma Treatment ... #Rheumatology #