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diagnosis hematology anemia globulin hemolytic oncology paraproteinemias protein proteingap rheumatology
Cutaneous Manifestations of Monoclonal Gammopathy • Extravascular lg Deposits: Systemic amyloidosis, Nodular amyloidosis, Macroglobulinoderma, Follicular hyperkeratotic
Cutaneous Manifestations ... of Monoclonal Gammopathy ... agglutinin disease ... #gammopathy #Cutaneous ... #dermatology #skin
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin ... Cold Agglutinins ... Agglutinin Disease ... Agglutinin Syndrome ... #agglutinin #disease
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cryoglobulinemia Associated Disorders ... Clinical Manifestations ... cryoglobulins • Negative causes ... Biopsy: Typical pathologic ... Antiphospholipid syndrome
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
gangrenosum • Cutaneous ... hypertrichosis, hyperpigmentation ... anemia due to cold ... Pseudohyponatremia • ↓anion gap ... #Monoclonal #Differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Causes of Monoclonal ... skin changes (POEMS ... syndrome) • Solitary ... Connective tissue disorders ... ovarian tumors, lung cancers
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