19 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Disease: Primary Biliary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Autoimmune hepatitis, PBC ... stone, Malignancy, PBC ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Primary Biliary ... relative with PBC ... T-cell mediated BEC injury ... Cholestasis #PBC ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Cirrhosis (PBC) ... - Summary PBC ... 30-65 years PBC ... Pathophysiology ... • Fatigue PBC
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Ducts - PBC ... - CBD stone, Biliary ... LFTs #Elevated #Abnormal ... Algorithm #diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
of Acute Liver Injury ... hepatitis, Acute biliary ... Malignancy, 1° PBC ... Extrahepatic • Biliary ... Acute #algorithm #hepatology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
WBC, patients with ... relative to both WBC ... WBC count had a ... #CBC #hematology ... #pathophysiology
hematopoiesis - leukocyte maturation tree

- Amy Chung, MD, MSc @AmyChung 

#hematopoiesis #leukocytes #maturation #tree #pathophysiology #Hematology
Amy Chung, MD, MSc ... maturation #tree #pathophysiology ... #Hematology #Progenitor ... #Cells #WBC #pathology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
- If both are normal ... • Bilirubin: RBC ... cardiac muscle, RBC ... • LDH: Heart, RBC ... #differential #Hepatology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
Myelodysplastic Disorder - Abnormal ... Myeloproliferation Disorder - Abnormal ... bcr-able (+) ↑ WBC ... Amy Chung, MD, MSc ... Blood #Disorders #hematology