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extravascular hemolysis algorithm aplastic chronic classification common cvid hemophagocytic hlh hypogammaglobulinemia immunodeficiency leukemia lymphocytic lymphohistiocytosis lymphoma mds myelodysplasia myelodysplastic summary
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... G6PD deficiency) ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Hemolysis - Differential ... anemia • ... Differential #Diagnosis ... #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Lymphoma - Clinical ... nodosum • Immune hemolytic ... Lymphoma Workup ... classification #hematology ... #oncology #management
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Cytopenias: • Neutropenia ... , anemia, thrombocytopenia ... #workup #oncology ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Hemopathies+++: Hodgkin ... (DLBCL, intravascular ... #management #treatment ... #summary #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... Difficulty breathing • Neutropenia ... and petechiae Causes ... #oncology #hematology ... #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to 8 years Clinical ... and autoimmune hemolytic ... anemia) • Systemic ... DDX - Other causes ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Myeloproliferative Disease • Neutropenia ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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