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diagnosis oncology hemolytic causes hemolysis agglutinin algorithm aplastic atlas chronic classification disorders gap hodgkins intravascular key lymphocytic lymphoma monoclonal morphology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... coagulation (DIC ... • Intrinsic RBC ... #diagnosis #hematology ... #anemia
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Bandemia Overview ... Even with normal WBC ... relative to both WBC ... bacteremia • Abnormal WBC ... #WBC #CBC #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology ... coagulopathy (DIC ... ) #RBC #Morphology ... key #diagnosis #differential ... #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
MAHA: TTP, HUS, DIC ... 2) External (RBC ... 3) Internal (RBC ... anemia, Thalassemias ... #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... hypertension • Unusual RBC ... acanthocytes - Consider RBC ... ARUPLabs #Hemolytic #Anemia ... #hematology #testing
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Lymphocytosis on CBC ... • Neutropenia, anemia ... #diagnosis #workup ... #oncology #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... virus (EBV) • Leukemia ... : • ↓ RBC • ... ↓ WBC • ↓ PLT ... #oncology #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
decreased PLT count: CBC ... changes), high MCV anemia ... ), HBsAg/anti-HBc ... ITP, unexplained pancytopenia ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... • hemolytic anemia ... Blood smear - RBC ... #hemolytic #anemia ... #hematology #diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... autoimmune hepatitis, PBC ... gastric tumors • Hematology ... anemia • Other ... #diagnosis #hematology
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