9 results
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
for a Prolonged PT ... and aPTT If the PT ... Pre-analytical cause (e.g. heparin ... thrombin inhibitors, heparin ... #differential #hematology
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Diagnosis and Management ... hemoglobin/hemosiderin, Hepatic ... antiglobulin test, PT ... hemosiderin • PT ... #Algorithm #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
unfractionated heparin ... deficiencies: Contact pathway ... cause e.g. heparin ... to the common pathways ... #differential #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
FXIIa (intrinsic pathway ... thrombin #clot #PT ... diagnosis #models #hematology ... Rivaroxaban #Edoxaban #heparin ... #pathway
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
the intrinsic pathway ... Acquired: • Heparin ... the extrinsic pathway ... in the common pathway ... Differential #Diagnosis #Hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT ... organ damage Clinical ... Fibrinogen: ↓ • PT ... causes #treatment #management ... #hematology
Our approach to the diagnosis and initial management of patients with suspected HIT. Our approach is
diagnosis and initial management ... based primarily on clinical ... #Diagnosis #Management ... #Hematology #HIT ... #Heparin #Induced
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
Diagnosis and Management ... Diagnosis: • Clinical ... Management: • ... A/C if clinical ... #Treatment #Hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
fever syndromes Clinical ... Fever is the main clinical ... Hypofibrinogenemia • ↑ PT ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology