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diagnosis hematology coagulation immunology anticoagulant anticoagulation apixaban bleeding bruising c5c9deficiency cardiology cardiomyopathy causes clot dabigatran edoxaban enzymes glomerulonephritis hemostasis heparin
Review of the Coagulation Cascade Traditional Model: • Parallel extrinsic and intrinsic pathways. Contemporary Model: • 4 key
the Coagulation Cascade ... and intrinsic pathways ... (i.e. common pathway ... #Coagulation #Cascade ... #hematology #pathophysiology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin (extrinsic pathway ... FXIIa (intrinsic pathway ... PTT #diagnosis #models ... #hematology #pathophysiology ... Edoxaban #heparin #pathway
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
fatality is rare Normal ... pathway is a non-specific ... alternative, or lectin pathway ... cascade -> MAC ... #pathophysiology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
integrity Clotting cascade ... the intrinsic pathway ... the extrinsic pathway ... in the common pathway ... and extrinsic pathways
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
the classical pathway ... (see Complement ... sites (e.g. lymph nodes ... proliferate and differentiate ... Humoral #Immunity #pathophysiology
Medical Conditions Causing Mania or Mania-Like Episodes: Pathogenesis • Bipolar Disorder -> Combination of individual, genetic,
demyelination alters normal ... neurotransmitter pathways ... methionine (SAM) pathway ... Secondary #Causes #Differential ... #Diagnosis #Pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Idiopathic • Normal ... Complement: IgA ... Glomerulonephritis #Vasculitis #differential ... #diagnosis #algorithm
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... determine choice of pathway ... for users of the pathway ... #Algorithm #Hepatology ... Liver #Enzymes #Differential
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
Differential Diagnosis ... unknown • Final pathway ... sx overlap with normal ... Planning for delivery mode
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