14 results
Complement Pathways
- Classical Pathway
- Lectin Pathway
- Alternative Pathway

#Complement #Pathway #hematology #pathophysiology
Complement Pathways ... - Classical Pathway ... - Lectin Pathway ... #Pathway #hematology ... #pathophysiology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
and extrinsic pathways ... in the common pathway ... to the common pathway ... amyloidosis #Abnormal ... #differential #hematology
Pathophysiology of Hypocomplementemic Urticarial Vasculitis

C1q/anti-C1q antibiody ->
Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Pathway Activation ... Vasculitis #HUV #Pathophysiology ... #Rheumatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
PT/ABNORMAL PTT ... the intrinsic pathway ... the extrinsic pathway ... in the common pathway ... and extrinsic pathways
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... deficiencies: Contact pathway ... to the common pathways ... Jcortesizaguirr #Abnormal ... #differential #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin (extrinsic pathway ... FXIIa (intrinsic pathway ... thrombin #clot #PT ... #pathophysiology ... Edoxaban #heparin #pathway
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
BEARING CHILD PATHWAY ... splenomegaly, abnormal ... cell disease Rheumatology ... #Limping #NWB #Algorithm ... #Pathway #Child
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
fatality is rare Normal ... : The complement ... pathway is a non-specific ... alternative, or lectin pathway ... #pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... Idiopathic • Normal ... Complement: IgA ... differential #diagnosis #algorithm ... #rheumatology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... tests algorithm ... determine choice of pathway ... for users of the pathway ... #Algorithm #Hepatology