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diagnosis glomerular nephrology nephrotic testing workup allergy c5c9deficiency cryoglobulinemia cryoglobulins gammopathy glomerulonephritis hypersensitivity immunology initial mgrs monoclonal nephritic nephritis reactions
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
meningococcal disease ... pathway is a non-specific ... Bacterial infection -> Classical ... alternative, or lectin pathway ... #pathophysiology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
during hemolytic disease ... Complement activation ... #Classification ... #Pathophysiology ... Diagnosis #Reactions #Table
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Through 2 Different Pathways ... • Autoimmune diseases ... Types: • Type ... • Low serum C4 complement ... #classification
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
for glomerular disease ... that activate the classical ... or alternative complement ... pathways. ... cryoglobulinemias (types
Recommended initial testing for patients being evaluated for glomerular disease 1) 24-hour urine collection - Quantify proteinuria.
for glomerular disease ... that activate the classical ... or alternative complement ... pathways. 6) SPEP ... cryoglobulinemias (types
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
refers to kidney disease ... guide subtype classification ... tubulopathy) - Complement ... pathway activation ... vasculitis Types
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