13 results
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
fatality is rare Normal ... : The complement ... pathway is a non-specific ... alternative, or lectin pathway ... #pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
RPGN has three primary ... pathophysiologic ... Idiopathic • Normal ... Glomerulonephritis #Vasculitis #differential ... #diagnosis #algorithm
Schematic representation of the major sources of ammonia production and its excretory pathway (GI = gastrointestinal,
its excretory pathway ... Portosystemic shunts - Urinary ... syndrome (Peds) - Primary ... deficiency #Ammonia #Pathophysiology ... Hyperammonemia #Differential
Medical Conditions Causing Mania or Mania-Like Episodes: Pathogenesis
 • Bipolar Disorder -> Combination of individual, genetic,
demyelination alters normal ... neurotransmitter pathways ... methionine (SAM) pathway ... Secondary #Causes #Differential ... #Diagnosis #Pathophysiology
Hypokalemia Differential Algorithm
Acidosis
 - RTA
 - Diarrhea
pH Normal 
 1. Decreased Mg 
 2. Intracellular Shift
Hypokalemia Differential ... Algorithm Acidosis ... - Diarrhea pH Normal ... Primary hyperaldo ... #Causes #Workup
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
tests algorithm ... determine choice of pathway ... for users of the pathway ... #Algorithm #Hepatology ... Liver #Enzymes #Differential
Humoral Immunity - Pathogenesis and Clinical Findings
Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... the classical pathway ... (see Complement ... proliferate and differentiate ... Humoral #Immunity #pathophysiology
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
Kidney Injury - AKI Workup ... Algorithm and Differential ... investigations abnormal ... #Injury #AKI #Workup ... #Algorithm #Differential
Primary and Secondary Causes of Hypertension - Differential Diagnosis Algorithm
Primary (Essential) (95%) - Onset between age
Hypertension - Differential ... Diagnosis Algorithm ... Mislabelled - Repeatedly normal ... taken at home, work ... #Diagnosis #Algorithm
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... 65 years PBC Pathophysiology ... bile ducts Differential ... malignancy #Primary ... cholangitis #diagnosis #workup