6 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Idiopathic • Normal ... Complement: IgA ... differential #diagnosis #algorithm
C5-C9 Deficiency - Pathogenesis and Clinical Findings
Note:
 • Risk of invasive meningococcal disease is 1000-10000x higher
fatality is rare Normal ... : The complement ... pathway is a non-specific ... alternative, or lectin pathway ... #pathophysiology
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... pathways. ... #workup #diagnosis ... #glomerulonephritis
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
tests algorithm ... determine choice of pathway ... decision for repeat testing ... for users of the pathway ... #Algorithm #Hepatology
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
Recommended initial testing ... or alternative complement ... pathways. 6) SPEP ... glomerular #disease #workup ... diagnosis #initial #testing
Monoclonal Gammopathy of Renal Significance (MGRS)

MGRS
• MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney function • Abnormal ... Diagnostic Workup ... tubulopathy) - Complement ... pathway activation