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management anemia bruising hemolysis intravascular lupus macrophage mas nephrology peds purpura renal scleroderma sle src systemic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... (usually IgG) (e.g ... (usually IgM) (e.g ... #Causes #differential ... #diagnosis #hematology
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
infiltration (e.g ... Rare disorders, e.g ... - Vasculitis, e.g ... #peds #pediatrics ... #diagnosis #differential
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
underlying disease (eg ... • Infection (eg ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... • Malignancy (e.g ... Endocrine disorders (e.g ... Chronic B-cell activation ... #Diagnosis #Rheumatology
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
(SRC) Clinical ... microangiopathic hemolytic ... other pathology (e.g ... (short-acting, e.g ... #rheumatology #
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