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diagnosis hematology oncology anemia aplastic apml capillary clarksons dermatology differentiation disease hemophagocytic hlh leak lymphohistiocytosis macrophage mas sapho timeline
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... rapidly, and empiric antibiotic ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... SLE], AOSD) • Infection ... Treatment: • Corticosteroids ... #Management #Hematology ... #Rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Neutropenia - recurrent infections ... - β-lactam antibiotics ... Idiopathic • Infections ... aplastic anemia Treatment ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Imaging: CXR- pulmonary ... Differential Diagnosis: Infection ... APML #diagnosis #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
causes such as infectious ... and lower jaw Treatment ... with acne: antibiotics ... #Rheumatology # ... diagnosis #management
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... filling +++ (risk of pulmonary ... of infections) ... #diagnosis #management ... #rheumatology
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