19 results
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Infectious • ... Malignant • Lymphoma ... • Leukemia ... Myeloproliferative disorders ... #Causes #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Causes of Eosinophilia - Differential Diagnosis
Bugs:
 - Fungus (aspergillosis)
 - Viral (HIV)
 - Ectoparasites (scabies, myiasis)
Asthma Tugs (vasculitis ... Primary: - CML - Lymphomas ... Hypereosinophilic Syndrome ... #Diagnosis #Causes ... #hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Clinical features ... : Pain in involved ... involved) • No leukemic ... Hepatosplenomegaly, cytopenias(bleeding ... hematology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... , bleeding, infections ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... e.g. lupus, CLL, lymphoma ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... Diagnosis: Vasculitis ... Polyangiitis #GPA #dermatology ... #rheumatology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... weeks without infection ... cells can indicate disease ... lymphoproliferative disorders ... #oncology #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Cold Agglutinin Syndrome ... Clinical Presentation ... chills, flank pain ... hemolytic #anemia #hematology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... to 8 years Clinical ... • Nodules • Lymphoid ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology