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leukemia lymphocytic agglutinin apml classification cold cvid differentiation erythematosus hemeonc hemolytic hodgkins hypogammaglobulinemia immunodeficiency immunology lupus mds myelodysplasia myelodysplastic sle
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... weeks without infection ... aplasia • ITP ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... , bleeding, infections ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Complications: 1) Infection ... lymphoma (Richter ... #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... • Nodules • Lymphoid ... autoimmune hemolytic anemia ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Monoclonal - Lymphoid ... symptoms - most common ... younger pts) Differential ... chills, flank pain ... #hematology #diagnosis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... • Pain in LN ... Treatment • Early ... #hematology #oncology ... #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
• Induce blast cell ... initiation • Differential ... Diagnosis: Infection ... #management #hematology ... #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Most common cytopenia ... • Aplastic Anemia ... Marrow Failure • Chronic ... Myeloproliferative Disease ... #hematology #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
fibromyalgia) • Infections ... Arthritis: • Joint pain ... common • Antihistone ... with Lupus: • Chronic ... #Rheumatology
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