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algorithm causes hes management oncology allergy eosinophil erythematosus hypereosinophilic leukocytosis lupus mds monoclonal myelodysplasia myelodysplastic paraproteinemias sle syndromes systemic tryptase
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
suspect underlying hematologic ... disorders • Diagnosis ... and Treatment Algorithm ... #Hematology #eosinophilia ... #eosinophils #diagnosis
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
attributable to eosinophilia ... with blood eosinophilia ... hypersensitivity - Infection ... #eosinophilia #diagnosis ... #hematology #differential
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... glucocorticoid treatment ... #Differential # ... diagnosis #hematology ... #eosinophilia
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Causes of Eosinophilia ... Asthma Tugs (vasculitis ... Syndrome - Chronic ... Eosinophilic Leukemia ... #hematology
Causes of Leukocytosis and Leukopenia - Differential Diagnosis • Eosinophilia (AEC > 500, hypereosinophilia > 1500):
Leukocytosis and Leukopenia ... - Differential ... Diagnosis • Eosinophilia ... (AEC > 500, hypereosinophilia ... #hematology
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
ESRD & CAD • Eosinophilic ... GI Disorders ... • Parasitic infections ... cell activation syndrome ... #Diagnosis #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... to exclude are infections ... differential #diagnosis ... #rheumatology # ... classification
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... Episodic angioedema+eosinophilia ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Skin Disease Classification ... permanent alopecia Differential ... fibromyalgia) • Infections ... • AIHA 10% • Leukopenia ... #Rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... blood cell count (leukopenia ... • Parvovirus infection ... blood count with differential ... #diagnosis #hematology
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