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hematology adultonset aosd lupus oncology sle adult antinxp2 antinxp2dm chronic comparison dermatology dermatomyositis druginduced erythematosus fungal infections infectiousdiseases leukemia lymphocytic
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Arthralgia/arthritis, Skin ... rash ± odynophagia ... #Disease #diagnosis ... #management #treatment ... #rheumatology
Adult-Onset Still's Disease (AOSD) Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Rare inflammatory disorder ... maculopapular rash ... episode (30%) Systemic ... #rheumatology #diagnosis ... #management #treatment
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Hepatomegaly • Skin ... cells can indicate disease ... lymphoproliferative disorders ... microglobulin Treatment ... #workup #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
• Adult-onset Still ... disease • Systemic ... or purpuric rash ... #Management #Hematology ... #Rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... Disease Systemic ... maculopapular skin ... #diagnosis #rheumatology ... #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Differential Diagnosis ... arthritis, adult-onset Still ... activation and/ ... #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
NPSLE rare, Malar rash ... months to years) Systemic ... Evolution: Chronic disease ... comparison #table #rheumatology ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... caused by bleeding (petechiae ... Myeloproliferative Disease ... Myelodysplastic #Syndromes #diagnosis
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
But can still have ... (blue-purple) rash ... had more severe disease ... positive patients Treatment ... #management #rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... osteomyelitis or skin ... the circulatory system ... Mouth, throat, skin ... #Management #Infections
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