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differential algorithm generalized lymphocytic pruritus common cvid erythematosus hypogammaglobulinemia immunodeficiency immunology lupus mds myelodysplasia primary rheumatology sle sweet syndromes thrombocytosis
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... inflammatory disorders ... syndrome • Myelofibrosis ... myeloid leukemia ... #Causes #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... extramedullary disease ... lymphoma #Leukemia ... #Hematology #Oncology ... #Diagnosis
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Creatinine & BUN: • Chronic ... Differential: • Lymphoma ... • Leukemia ... syndrome Psychiatric ... #dermatology #Differential
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can indicate disease ... • Neutropenia, anemia ... #Leukemia #diagnosis ... #workup #oncology ... #hematology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
• Leukemia ... syndrome Psychiatric ... #systemic #generalized ... #dermatology #Differential ... #causes
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... in adults • Disorder ... #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Causes • Anemia ... Cell Leukemia ... #Syndromes #diagnosis ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... infection risk secondary ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
disease. ... Rare Disorder: ... Causes: - Idiopathic ... #diagnosis #dermatology ... #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... lymphoma • Evans ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic ... and leukemia •
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