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diagnosis differential hepatology injury atlas bloodcell causes common cvid dili druginduced fatigue gap globulin hypogammaglobulinemia immunodeficiency immunology management microscopy morphology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... hepatitis fibrosis ... steatosis • Autoimmune ... hepatitis #DILI ... #hepatology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
deficiency anemia, Chronic ... McLeod blood group phenotype ... spherocytosis, Autoimmune ... Agglutinate: Cold autoimmune ... differential #diagnosis #hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Differential Diagnosis Algorithm ... Renal Failure • Liver ... Neoplastic / Hematologic ... Epstein-Barr Virus • Hepatitis ... • HIV Autoimmune
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Celiac disease • Autoimmune ... : Autoimmune hepatitis ... > 2 • NASH, Chronic ... #hepatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... disease • Liver ... diseases and hepatitis ... Malignancies • Chronic ... hypogammaglobulinemia #immunology #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
first step in evaluation ... Sarcoidosis) • Liver ... Cirrhosis, ETOH, autoimmune ... gastric tumors • Hematology ... differential #diagnosis #hematology
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