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Status Epilepticus Pharmacotherapy Guide

 • Phenytoin and Fosphenytoin
 • Valproate Sodium
 • Levetiracetam
 • Lacosamide
 •
Pharmacotherapy Guide • Phenytoin ... management #epilepsy #seizure
Status Epilepticus 
Continuous seizure activity > 5-10 min OR >= 2 seizures without full recovery
First line
Epilepticus Continuous seizure ... 10 min OR >= 2 seizures ... Second line • Phenytoin ... mg/kg IV (Phenytoin
Antiseizure Drugs 
Sodium Channel Blockers: Carbamazepine, Oxcarbazepine, Eslicarbazepine, Lamotrigine, Lacosamide, Phenytoin, fosphenytoin
Broad Spectrum: Valproate, Levetiracetam, Brivaracetam,
Lamotrigine, Lacosamide, Phenytoin ... Primidone Absence Seizure
Patient with brain tumor. 
Seizures prophylaxis with phenytoin. 
Develops TEN (toxic epidermal necrolysis).
Nikolsky's sign

#Dermatology
#Nikolsky
#TEN
Seizures prophylaxis ... with phenytoin.
ConSEPT and EcLiPSE – Levetiracetam versus Phenytoin for Status Epilepticus - Visual Abstract
Don't Forget the Bubbles,
Levetiracetam versus Phenytoin ... not superior to phenytoin ... difference between phenytoin ... including time to seizure ... Levetiracetam #Phenytoin
Anti-Seizure Medication Guide - Common Uses and Side Effects

acetazolamide 
brivaracetam 
carbamazepine 
clobazam 
clonazepam 
clorazepate 
corticotropin injection
diazepam
Anti-Seizure Medication ... perampanel phenytoin ... Adverse #AEDs #seizure
Management of Convulsive Status Epilepticus in children
Stabilization Phase (Seizure 0-5 minutes):
 • Check and maintain ABC
Stabilization Phase (Seizure ... Epilepticus (Seizure ... minutes): • IV Phenytoin ... not on regular Phenytoin ... If seizure continues
Emergency Treatment Algorithm for Convulsive Status Epilepticus 
 1. ABCDEFG (ABC's and Don't Ever Forget the
Fosphenytoin or Phenytoin ... is available or seizure ... management #neurology #seizures
Management Algorithm for Status Epilepticus

• Assess airway, breathing, and circulation
• Pulse oximetry
• Electrocardiogram
• Finger stick (give
Second-line therapy: • Phenytoin ... pharmacology #dosing #seizure
MGH Status Epilepticus Treatment Protocol
1st line (seizures ongoing for 5-10 mins): 
 - Lorazepam 4mg IV
Protocol 1st line (seizures ... -30 mins) - If seizures ... 150mg PE/min) or, Phenytoin ... 10mg PE/kg IV or Phenytoin