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diagnosis management causes nephrology hypokalemia als cauda caudaequina encephalopathy equina gitelman gravis lateral manifestations myasthenia neurological pathophysiology posterior pres reversible
Weakness - Differential Diagnosis Framework Approach To Weakness: • Non-neuromuscular disorder (Cardiac, pulmonary etc) • CNS ->
Weakness - Differential ... Impairment: • Acute stroke ... syndromes • Space ... #Differential # ... Diagnosis #neurology
Amyotrophic Lateral Sclerosis (ALS) Summary ALS: combination of the clinical examination finding of amyotrophy with the pathologic
Amyotrophic Lateral ... examination finding of amyotrophy ... conditions listed in differential ... diagnosis column Treatment ... Lateral #Sclerosis #neurology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
variable degree of weakness ... Limb- proximal weakness ... life-threatening Differential ... Severe bulbar weakness ... diagnosis #management #neurology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Heat injury, Heat stroke ... Muscle pain - Weakness ... Rhabdomyolysis #Differential ... #nephrology
Neurological Manifestations of Tuberculosis Spinal Arachnoiditis & Polyradiculopathy: • Subacute onset of limb weakness, bladder/bowel dysfunction, muscle
onset of limb weakness ... Reconstitution Inflammatory Syndrome ... or hemorrhagic stroke ... Tuberculosis #diagnosis #differential ... #TB #neurology
Cauda Equina Syndrome Overview Cauda Equina Syndrome: • Prevalence: 1:33,000-100,000 ppl/yr • Incidence: 1.5-3.4 million ppl/yr •
constipation Differential ... lower extremity weakness ... axial T1 and T2 Treatment ... #differential # ... diagnosis #causes #neurology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
may precede the neurologic ... Reversible course Differential ... Constipation, Seizures, Stroke ... epilepticus Treatment ... underlying cause • Treatment
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... affects the skin, neurologic ... Myalgia and muscle weakness ... cognitive impairment, neurologic
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
plasma insulin (treatment ... use), Gitelman's syndrome ... exercise, Heat stroke ... Hypokalemia #Causes #differential ... #diagnosis #nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... Fatigue • Muscle weakness ... ratio 0.5%) Differential ... Rhabdomyolysis Treatment ... #diagnosis #nephrology
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