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diagnosis differential hepatology liver management primary acute injury pbc abdominalpain bile choledocholithiasis clinical duct ercp jaundice lfts ophthalmology pain ruq
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
genes coding for bile ... miscellaneous causes ... mononucleosis, cholangitis ... duct, sclerosing cholangitis ... #differential #causes
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... hepatitis - Acute biliary ... Hemochromatosis - Primary biliary ... cholangitis ... Severe #Acute #Causes
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Differential Diagnosis Algorithm ... • Bacterial Cholangitis ... Primary Sclerosing Cholangitis ... • Primary Biliary ... #Causes #Hepatology
Right Upper Quadrant Pain Liver: - Infectious: Acute viral hepatitis, Liver abscess - Non-infectious: hepatitis (Alcohol, Medications),
Budd-Chiari syndrome Biliary ... cholecystitis, Acute cholangitis ... "ascending cholangitis ... "biliary colic") ... differential #diagnosis #causes
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
Differential Diagnosis Algorithm ... on Ultrasound Biliary ... Gallstones • Biliary ... Primary Sclerosing Cholangitis ... #Causes #Hepatology
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Causes of Ascites ... Differential Diagnosis Algorithm ... failure • Primary biliary ... cholangitis • ... #Hepatology #causes
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Differential Diagnosis Algorithm ... Intestine - Other causes ... Cholangitis (PBC ... PSC - Other biliary ... diseases/Bile duct
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... ducts causes cholestasis ... No extrahepatic biliary ... sclerosis group cholangitis ... Cirrhosis #PBC #cholangitis
Gallstone Diseases 1. Asymptomatic Stones 75% 2. Biliary Pain 20% 3. Acute Cholecystitis 10% 4. Mirizzi's Syndrome < 0.1% 5. Cholangitis/
Biliary Pain 20% ... Cholangitis/ Pancreatitis ... differential #diagnosis #causes
ACUTE CHOLANGITIS Legend says that Cholangitis was first defined in 1877 by Jean-Martin Charcot, at which time
ACUTE CHOLANGITIS ... the obstructed bile ... cholē” meaning bile ... infection of the biliary ... individuals with biliary
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