7 results
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
circulates with albumin ... Released from albumin ... Laboratory #Metabolism #ASTALT ... #Hepatology #Pathophysiology ... #Diagnosis #LFTs
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... function: INR, bilirubin ... , albumin Post-Hepatic ... sarcoidosis) • Liver ... #causes #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Production: • Albumin ... normal AST/ALT AST ... hepatitis: < 1 • Cirrhosis ... #chemistry #diagnosis ... #differential #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... be abnormal AST ... hepatitis: < 1 • Cirrhosis ... #differential #diagnosis ... #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
65 years PBC Pathophysiology ... /Liver failure ... slightly elevated • Bilirubin ... or higher • Liver ... #workup #hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... DIC • Severe Liver ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
thrombocytopenia • Liver ... ↑ AST ↑ ALT ↑ bilirubin ... Hypofibrinogenemia • ↑ PT ↑ PTT ... Activation #Syndrome #Diagnosis ... #Management #Hematology