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differential treatment syndrome algorithm causes chemistry hbv hepatitisb hepatopulmonary lfts primary psc activation alkphos astalt biliary chronic coagulation comparison dic
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Primary Biliary Cirrhosis ... Primary Sclerosing Cholangitis ... #pathophysiology ... #pbc #psc #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Pathophysiology ... /Liver failure ... slightly elevated • Bilirubin ... #PBC #cholangitis ... #hepatology
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Phosphatase and Bilirubin ... circulates with albumin ... Released from albumin ... #Hepatology #Pathophysiology ... #Diagnosis #LFTs
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... stone, Malignancy, PBC ... hepatitis: < 1 • Cirrhosis ... #differential #diagnosis ... #algorithm #hepatology
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
asymptomatic at diagnosis ... • CHOLANGITIS ... disease management ... #diagnosis #management ... #summary #Hepatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... function: INR, bilirubin ... , albumin Post-Hepatic ... sarcoidosis) • Liver ... #causes #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
week • Direct bilirubin ... Production: • Albumin ... hepatitis: < 1 • Cirrhosis ... #chemistry #diagnosis ... #differential #Hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Presence of CP or PC ... injury (INR > 2, bilirubin ... mg/dL) or acute liver ... #Indications #management ... #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Hepatitis B - Diagnosis ... and Management ... viremia or have cirrhosis ... • Monitor: CBC ... #Hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... DIC • Severe Liver ... #Coagulation #diagnosis ... causes #treatment #management ... #hematology
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