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diagnosis differential treatment algorithm hepatitisb primary psc biliary causes chemistry chronic coagulation comparison dic disseminated gap globulin hepatitis hepbv indications
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis #pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Primary Biliary Cirrhosis ... Primary Sclerosing Cholangitis ... #pathophysiology ... #pbc #psc #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Pathophysiology ... /Liver failure ... slightly elevated • Bilirubin ... #PBC #cholangitis ... diagnosis #workup #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
, HBV, HCV, HEV, ... Autoimmune hepatitis, PBC ... stone, Malignancy, PBC ... hepatitis: < 1 • Cirrhosis ... diagnosis #algorithm #hepatology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
Presence of CP or PC ... injury (INR > 2, bilirubin ... mg/dL) or acute liver ... #Indications #management ... #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Diagnosis and Management ... viremia or have cirrhosis ... • Monitor: CBC ... HAV immunity; Liver ... #Treatment #Hepatology
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
• CHOLANGITIS ... • CIRRHOSIS - ... disease management ... #diagnosis #management ... #summary #Hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
week • Direct bilirubin ... Production: • Albumin ... hepatitis: < 1 • Cirrhosis ... Elevation: • Bilirubin ... #differential #Hepatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT/PTT ... protein C and S Pathophysiology ... DIC • Severe Liver ... causes #treatment #management ... #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Total Protein - Albumin ... Sarcoidosis) • Liver ... disease: Cirrhosis ... gastric tumors • Hematology ... differential #diagnosis #hematology
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