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endocrinology menstrualcycle diagnosis growthhormone signs symptoms adenoma algorithm clinical comparison excess feedbackloop follicularphase glftap gnrh hand lutealphase macroadenoma management masseffects
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook Clinical Presentation: • Classic Acromegaly: frontal
malignancy Pathophysiology ... pituitary adenoma ... (Up to 30% of pituitary ... • Pituitary ... Endocrinology #Treatment #Pathophysiology
Acromegaly Caused by over-secretion of growth hormone (GH) from the pituitary gland. The condition is rare
Acromegaly Caused ... growth hormone (GH ... ) from the pituitary ... #Acromegaly #Signs
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... /Symptoms: • GH ... - Giantism or acromegaly ... endocrinology #pathophysiology ... #pituitary
Growth Hormone Excess - Pathogenesis and clinical findings • Acromegaly and gigantism share the same pathophysiology
clinical findings • Acromegaly ... share the same pathophysiology ... plate fusion -> acromegaly ... rare causes of acromegaly ... endocrinology #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Brief Overview LH and FSH are required for follicular development and
- FSH from pituitary ... - LH from pituitary ... LH release from pituitary ... MenstrualCycle #OvarianCycle ... #pathophysiology
Acromegaly in patient with a pituitary adenoma #acromegaly #pituitary #adenoma #GnRH #Hand #PhysicalExam #clinical #photo
Acromegaly in patient ... with a pituitary ... adenoma #acromegaly ... #pituitary #adenoma ... PhysicalExam #clinical #photo
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
Pituitary Mass Effects ... Pituitary adenomas ... • For pituitary ... following order; GH ... mnemonic #GLFTAP #pathophysiology
Acromegaly Testing Algorithm INDICATIONS FOR TESTING: • Adults – enlarged facial or acral features, abnormal musculoskeletal growth
Acromegaly Testing ... Growth Hormone (GH ... MRI to evaluate pituitary ... evaluation of other pituitary ... ARUPConsult @ARUPLabs #Acromegaly
Menstrual Cycle Physiology: Ovarian Cycle – Ovulation Explained Around Day 14, estrogen exerts sudden +++ positive feedback
on the anterior pituitary ... MenstrualCycle #OvarianCycle ... #pathophysiology
Menstrual Cycle Physiology: Ovarian Cycle – Follicular Phase Explained Early Follicular Phase (Days 0-5) • Granulosa cells
production by pituitary ... back on anterior pituitary ... production by pituitary ... MenstrualCycle #OvarianCycle ... #pathophysiology
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