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management apml differentiation encephalopathy erythematosus leukostasis lupus lysis neurology nutrition oncology posterior pres refeeding reversible rheumatology sle systemic tls tumor
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... : • Pathophysiology ... dysrhythmias, seizures ... #TLS #diagnosis ... #management #hematology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
• Headache • Seizures ... Etiology: • Pathophysiology ... Neurological symptoms ... Reversible course Differential ... : Treat with AEDs
Refeeding Syndrome Overview What Is It? • Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
Refeeding Syndrome ... overload) Other Symptoms ... Rhabdomyolysis • Seizures ... #Nutrition #Differential ... #Diagnosis #Pathophysiology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... : >3 symptoms, or ... initiation • Differential ... #management #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... mood disorder • Seizures ... • Psychosis • Seizures ... Induced Lupus: • Symptoms
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