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management differential vasculitis hematology hemophagocytic hlh lymphohistiocytosis renal syndrome acidosis adultonset algorithm capillary cell clarksons diuresis diuretics elevation excretion glomerulonephritis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Differential Diaqnoses ... Coxsackie, CMV, EBV ... hepatitis • Pulmonary ... #diagnosis #management ... #treatment #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... With associated pulmonary ... Disease (Goodpasture's ... #differential #diagnosis ... #algorithm #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Autoimmune diseases ... Drugs, Unknown cause ... Treatment: • ... #management #treatment ... #summary #rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... antibody, Anti-GBM ... Goodpasture's cause ... #management #treatment
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... glomerulonephritis) • Anti-GBM ... #rheumatology # ... classification
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
presentations and disease ... perfusion - shock->treatments ... before beginning treatment ... output - Acute pulmonary ... #typeb #classification
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
150 published cases ... filling +++ (risk of pulmonary ... spacing of IVIg cures ... leak #syndrome #diagnosis ... #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... : • 10%-15% Pulmonary ... Adenocarcinoma Treatment ... lubricants • Pharmacologic ... Sjogrens #Syndrome #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis Differential Diagnosis ... tract, and often causes ... pain and GN Anti-GBM ... #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• History of EBV ... ) Classification ... number of sites of disease ... Hodgkin Lymphoma Treatment ... #classification
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