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diagnosis neurology gitelman causes differential hematology barre guillain lysis oncology rhabdomyolysis tls tumor apml brash cerebritis cns differentiation diuresis diuretics
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Pathophysiology ... distal tubule. ↑ Nacl ... H+ secretion → Hypokalemia ... Metabolic alkalosis ... #nephrology #diagnosis
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
hypomagnesemia • Metabolic alkalosis ... Hypochloremic metabolic alkalosis ... Rhabdomyolysis Treatment ... #diagnosis #nephrology ... #management #pathophysiology
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts: - Alkalosis ... plasma insulin (treatment ... diuresis, Bartter's syndrome ... use), Gitelman's syndrome ... differential #diagnosis #nephrology
BRASH Syndrome B - Bradycardia R - Renal failure A - AV nodal blockade S - Shock H - Hyperkalemia Typical ECG
BRASH Syndrome ... ) BRASH Treatment ... • Aggressive treatment ... #diagnosis #management ... #pathophysiology
Tumor Lysis Syndrome An acute, life-threatening condition that appears within 7 days of starting cytotoxic therapies in
Tumor Lysis Syndrome ... malignancies Treatments ... 6L/day) • For hyperkalemia ... #Tumor #Lysis #Syndrome ... TLS #oncology #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... have fever - ACS ... : • Pathophysiology ... hydration - Hyperkalemia ... TLS #diagnosis #management
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
and Management ... clear cause) Management ... Ca-gluconate or 1g CaCl ... #Treatment #potassium ... #nephrology #K
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... - Compartment syndrome ... Differential #Diagnosis #Management ... #causes #treatment ... #nephrology
Gitelman Syndrome - Management Treatment includes - Electrolyte replacement - K & Mg, preferably Cl salts
- Management Treatment ... Mg, preferably Cl ... In persistent hypokalemia ... #Management #Treatment ... #nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Diagnosis and Management ... iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... Dermatomyositis) AKI - Pathophysiology ... Dialysis for severe hyperkalemia
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