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diagnosis management differential causes hyperkalemia rhabdomyolysis gitelman hypokalemia medications pharmacology summary syndrome
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... differential #diagnosis #pathophysiology ... #pharmacology #potassium ... #medications #druginduced
Hyperkalemia Treatment Options Stabilize cardiac membrane: • IV Calcium (peaks 5-10 minutes) Decrease potassium concentration: • IV Fluids Shift
Hyperkalemia Treatment ... minutes) Decrease potassium ... • IV Fluids Shift ... potassium intracellularly ... #nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... oxidative iniury Treatment ... Monitor potassium ... Summary #causes #treatment
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Shift of extracellular ... oxidative injury Treatment ... Treatment of underlying ... Monitor potassium ... #nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Hypokalemia (renal potassium ... Rhabdomyolysis Treatment ... Supplement: • Potassium ... Syndrome #diagnosis #nephrology ... #management #pathophysiology
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