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Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
and Management ... malignancy Pathophysiology ... Differential Diagnosis ... #Endocrinology ... #Treatment #Pathophysiology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
deficiency: - Short ... - Giantism or acromegaly ... #FeedbackLoop #endocrinology ... #pathophysiology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Hypocalciuria (spot ... ratio 0.5%) Differential ... diagnosis #nephrology #management ... #pathophysiology