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diagnosis management hematology oncology apml chronic differential differentiation fungal hemophagocytic hlh infections infectiousdiseases leukemia leukostasis lupus lymphocytic lymphohistiocytosis lysis mds
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Physical Exam/Signs ... microglobulin Treatment ... • Richter’s Syndrome ... leukemia • Sezary syndrome
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... WBC >100k, + lab signs ... : • Pathophysiology ... diagnosis #management #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... • Malar rash - spares ... Induced Lupus: • Symptoms ... : • Chronic B-cell ... #Diagnosis #Rheumatology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
age 70 years Symptoms ... Pinpoint-sized red spots ... factor (GCSF) treatments ... marrow studies Treatment ... #diagnosis #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... Pathophysiology ... • Induce blast cell ... Diagnosis: >3 symptoms
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... Diagnosis: HLH signs ... and symptoms can ... Low or absent NK cell ... #hematology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... ischemia • Skin: Erythematous ... • Progressive symptoms ... Differential #Diagnosis #Rheumatology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
systemic lupus erythematosus ... lymphoma Pathophysiology ... and the systemic symptoms ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
Males • Affects all ... ethnicities Symptoms ... + Nonspecific symptoms ... affected tissue Treatment ... Polychondritis #rheumatology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
• Rheumatologic ... Inhalation of spores ... Hematopoietic stem cell ... Aspergillosis Pathophysiology ... becomes a yeast cell
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