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diagnosis hematology blood druginduced reactions sle treatment classification comparison cryofibrinogenemia cryoglobulins erythematosus hemophagocytic hlh lymphohistiocytosis systemic table transfusion transfusions types
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Summary • Epidemiology ... Manifestations: Malar ... of SLE versus DIL ... Positive in 60-80% of cases ... #Summary #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Discontinuation of causal ... Manifestations: Malar ... comparison #table #rheumatology ... #diagnosis #management
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Summary Cryoglobulins ... causing endothelial injury ... • They can cause ... (e.g. systemic lupus ... classification #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Summary ... of fibrin split products ... • Fibrin split products ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... & NPSLE rare, Malar ... Discontinuation of causal ... #DIL #rheumatology ... diagnosis #treatment #management
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
One Pager Summary ... pain, dark urine, DIC ... Related Acute Lung Injury ... tested include: Malaria ... Transfusions #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Leishmaniosis, malaria ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management ... #treatment #summary ... #rheumatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
pain, dark urine, DIC ... Related Acute Lung Injury ... tested include: Malaria ... Transfusion #diagnosis #management ... #hematology #reactions
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