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diagnosis management hematology blood druginduced product reactions treatment anemia classification comparison cryoglobulins differential erythematosus extravascular hemolysis hemolytic hemophagocytic hlh intravascular
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
and Management Summary ... Manifestations: Malar ... versus DIL • ... Positive in 60-80% of cases ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Lupus (DIL): ... & NPSLE rare, Malar ... , SCLE-DIL (terbinafine ... Manifestations: Malar ... #table #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Summary Cryoglobulins ... causing endothelial injury ... • They can cause ... (e.g. systemic lupus ... classification #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... HUS) • Other: Transfusion ... usually IgG) (e.g. lupus ... • Infections: Malaria ... Extravascular #Causes
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
One Pager Summary ... pain, dark urine, DIC ... Causes purpura & ... Related Acute Lung Injury ... tested include: Malaria
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
pain, dark urine, DIC ... Causes purpura & ... Related Acute Lung Injury ... TRALI): Leading cause ... tested include: Malaria
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Leishmaniosis, malaria ... Autoimmune diseases: SLE ... Drugs, Unknown cause ... management #treatment #summary ... #rheumatology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... & NPSLE rare, Malar ... , SCLE-DIL (terbinafine ... Discontinuation of causal ... #DIL #rheumatology
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