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diagnosis differential hematology erythematosus sle systemic causes extravascular fever hemolysis hemolytic infectiousdiseases intravascular macrophage management mimickers monoclonal oncology paraproteinemias signs
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... - Hemolytic anemia ... sclerosis, Still's disease ... Erythematosus #Diagnosis #autoantibodies ... #differential #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... Hemolytic uremic syndrome ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #anemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Anti-Ro/SSA autoantibodies ... Non-autoimmune rheumatologic ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia ... Chronic B-cell activation
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Syndrome (MAS) ... • Systemic lupus ... with leukopenia, anemia ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... myopathy • Anti MAG ... macular Vasculitis) Autoantibodies ... (-) hemolytic anemia ... to cold IgG • Lupus
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
region Viral Syndromes ... ; dengue shock syndrome ... leak syndrome with ... No hemolytic anemia ... Babesiosis • Plasmodium
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