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diagnosis hematology hemolytic erythematosus sle systemic agglutinin algorithm autoantibodies causes classification cold disease extravascular hodgkins infectiousdiseases intravascular lymphoma management mimickers
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgG) (e.g. lupus ... • Infections: Malaria ... Extravascular #Causes #differential ... #anemia
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... rash 40% - Fever ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... suspected, consider malaria ... bartonella (oroya fever ... #Anemia #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
of anemia include ... anemia • Cold ... younger pts) Differential ... : High fevers, chills ... #anemia #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
weight loss, and fever ... permanent alopecia Differential ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia ... : • Symptoms limited
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
No hemolytic anemia ... Babesiosis • Plasmodium ... and myalgias, symptoms ... • Falciparum malaria ... #Travel #Differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... nodosum • Immune hemolytic ... anemia • Pain ... ingestion • B symptoms ... Immunohistochemical studies (to differentiate
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