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diagnosis differential hematology hemolytic management product reactions algorithm babesia babesiosis clinical extravascular hemolysis infectiousdiseases intravascular microti peripheral smear transfusions travel
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
• Peripheral blood ... disease, drugs, transfusions ... Recent travel/Fevers ... Malaria, Clostridium ... Diagnosis #Algorithm #causes
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... • Infections: Malaria ... Extravascular #Causes ... #anemia
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Blood Product Transfusions ... Crossmatch - involves testing ... S/sx: Fever, flank ... false negatives on testing ... tested include: Malaria
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Blood Transfusion ... S/sx: Fever, flank ... Causes purpura & ... false negatives on testing ... tested include: Malaria
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
No hemolytic anemia ... Babesiosis • Plasmodium ... renal function • Blood ... a chest film; blood-smear ... and possibly PCR testing
Babesiosis on Peripheral Smear 85 M from SE USA, hx splenectomy, IgG4 plasmacytic syndrome: F, chills, profound
Transfusion related ... post exchange: blood ... babesia microti, malaria ... , anemia, jaundice ... ARDS and DIC, case
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