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diagnosis erythematosus signs sle symptoms systemic ana antinuclear arthritis autoantibodies classification comparison disease extravascular hematology hemolysis hemolytic intravascular laboratory management
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... - Hemolytic anemia ... SLE-Related Auto-Antibodies ... (aPL) 30-45% Differential ... #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #differential # ... #anemia
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... assay (IFA) is the main ... healthy adults, and should ... ANA #patterns #rheumatology ... #diagnosis #differential
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism In contrast to the
Features That Differentiate ... associated with rheumatologic ... presentation of systemic lupus ... trapezius ridges or shoulders ... life-threatening causes
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 SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Arthritis: • Joint pain ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... inflammation Others: • Lupus ... such as systemic lupus ... C-ANCA) pattern: antibodies ... #diagnosis #rheumatology
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
disease of unknown cause ... proximal muscle pain ... • Normocytic anemia ... normal and can help differentiate ... Diagnosis #Management #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... double-stranded DNA antibodies ... ANAs RF test should ... the presence of anemia ... , and low back pain
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