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diagnosis disease erythematosus hematology sle systemic agglutinin ana antinuclear arthritis autoantibodies causes cold extravascular hemolysis intravascular laboratory management mimickers patterns
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgG) (e.g. lupus ... • Infections: Malaria ... Extravascular #Causes #differential ... #anemia
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... SLE-Related Auto-Antibodies ... #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Sensitive Antibodies ... anemia • Cold ... younger pts) Differential ... chills, flank pain ... #anemia #hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... assay (IFA) is the main ... healthy adults, and should ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Arthritis: • Joint pain ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
proximal muscle pain ... • Normocytic anemia ... anti-citrullinated peptide antibodies ... normal and can help differentiate ... Diagnosis #Management #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... double-stranded DNA antibodies ... ANAs RF test should ... the presence of anemia ... , and low back pain
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