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diagnosis management hematology blood erythematosus product sle symptoms systemic vasculitis ana anemia antinuclear arthritis autoantibodies autoimmune classification comparison extravascular hemolysis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... SLE-Related Auto-Antibodies ... (aPL) 30-45% Differential ... autoantibodies #signs ... #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #differential # ... diagnosis #hematology
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism In contrast to the
associated with rheumatologic ... presentation of systemic lupus ... trapezius ridges or shoulders ... life-threatening causes ... Pericarditis #Symptoms #Signs
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 Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... assay (IFA) is the main ... healthy adults, and should ... ANA #patterns #rheumatology ... #diagnosis #differential
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
: Fever, flank pain ... Causes purpura & ... TRALI): Leading cause ... tested include: Malaria ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
: Fever, flank pain ... Causes purpura & ... TRALI): Leading cause ... more likely to cause ... tested include: Malaria
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Arthritis: • Joint pain ... Photosensitivity • Malar ... 1, SCL-70, RNP antibodies
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
- Arthritis Differential ... axial (spine, shoulders ... noninflammatory Signs ... weeks) Can Be Caused ... #Differential #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... disease, drug reactions ... purpura: strong sign ... C-ANCA) pattern: antibodies ... #diagnosis #rheumatology
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
disease of unknown cause ... proximal muscle pain ... anti-citrullinated peptide antibodies ... normal and can help differentiate ... Diagnosis #Management #Rheumatology
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