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diagnosis erythematosus hematology hemolytic sle systemic agglutinin ana antinuclear arthritis autoantibodies causes classification cold dermatology extravascular hemolysis intravascular joint laboratory
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... - Hemolytic anemia ... SLE-Related Auto-Antibodies ... (aPL) 30-45% Differential ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... assay (IFA) is the main ... healthy adults, and should ... ANA #patterns #rheumatology ... #diagnosis #differential
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgG) (e.g. lupus ... • Infections: Malaria ... Extravascular #Causes #differential ... #diagnosis #hematology ... #anemia
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint Pain ... B19 infection Malar ... lesions • Discoid lupus ... #skin #rashes #differential ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... Arthritis: • Joint pain ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Sensitive Antibodies ... Donath-Landsteiner Antibodies ... younger pts) Differential ... chills, flank pain ... #hematology #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Vasculitides - Differential ... inflammation Others: • Lupus ... such as systemic lupus ... C-ANCA) pattern: antibodies ... #diagnosis #rheumatology
Polymyalgia Rheumatica (PMR) Diagnosis and Management Summary WHAT? • Polymyalgia rheumatica (PMR) is a common systemic inflammatory
proximal muscle pain ... • Normocytic anemia ... anti-citrullinated peptide antibodies ... normal and can help differentiate ... Diagnosis #Management #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
joint • Systemic lupus ... double-stranded DNA antibodies ... ANAs RF test should ... the presence of anemia ... , and low back pain
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