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diagnosis management bleeding dermatology differential druginduced hemophagocytic hlh lymphohistiocytosis sle anemia antinxp2 antinxp2dm arthritis blood bruising comparison dermatomyositis endoscopy erythematosus
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
and Management Summary ... Manifestations: Malar ... of SLE versus DIL ... life-threatening • Treatment ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Discontinuation of causal ... Manifestations: Malar ... life-threatening • Treatment ... comparison #table #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... • Infections: Malaria ... Extravascular #Causes ... differential #diagnosis #hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
& NPSLE rare, Malar ... constitutional symptoms • Treatment ... Discontinuation of causal ... #DIL #rheumatology ... #diagnosis #treatment
Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
and Management Summary ... present, symptoms, signs ... aspirin • Aspirin should ... Diagnosis #Management #Summary ... #treatment #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Fibrinogen level, ↑ sIL ... Leishmaniosis, malaria ... Drugs, Unknown cause ... Treatment: • ... #summary #rheumatology
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
Rheumatoid Arthritis Summary ... hands/feet, knees, shoulders ... Signs & Symptoms ... exam and imaging Treatment ... diagnosis #management #rheumatology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... Rule out other causes ... and lower jaw Treatment ... SAPHO #Syndrome #Rheumatology ... diagnosis #management #Dermatology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor and lupus ... Willebrand syndrome • Lupus ... of factor VII should ... discern these causes ... Differential #Diagnosis #Hematology
Esophageal Variceal Bleeding - Diagnosis and Management Summary PRE-ENDOSCOPY Vasoactive agents - Octreotide: • 50mcg bolus →
and Management Summary ... Goal Hgb 7-9 g/dL ... unclear source (in case ... ligation - EGD should ... Diagnosis #Management #treatment
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