185 results
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... Defects #comparison #table ... #differential #
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... count and platelet ... 1 or Type 3) — differentiate ... • Platelet flow ... hematology #hemepath #differential
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Thrombocytosis - Differential ... Diagnosis Platelet ... Thrombocytosis #Differential ... Diagnosis #causes #Platelets
Idiopathic Thrombocytopenic Purpura 
Clinical:
 • Gingival 
 • Menorrhagia 
 • GI bleeding 
 • Intracranial
Intracranial hemorrhage Management ... children) • Platelets ... extremely low platelet
Thromboelastography (TEG) Based Management
 - If R time prolonged -> FFP 
 - If MA low
Thromboelastography (TEG) Based Management ... cryoprecipitate - If platelets ... < 50 -> platelet ... Thromboelastography #TEG #Management
Blood Product Components, Contents, Volume and Shelf Life

Whole blood (autologous or directed donations) - RBC and
WBC and platelets ... Hct 60% Platelet ... concentrate - Platelets ... Hct < .005) Platelet ... pheresis - Platelets
Thromboelastography (TEG) based therapy and Management

If r time prolonged -> FFP
If MA low -> plts/cryoprecipitate (if
based therapy and Management ... cryoprecipitate If platelets ... < 50 - > platelet ... Thromboelastography #TEG #Management
Indications for Transfusion
Packed RBCs
 • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
hemoglobinopathy Platelets ... Prophylactically for platelet ... not transfuse platelets ... Platelet transfusions ... #RBCs #Platelets
Causes of Acquired Platelet Dysfunction

#Acquired #Platelet #Dysfunction #Causes #differential #Diagnosis #hematology
Causes of Acquired Platelet ... #Acquired #Platelet ... Dysfunction #Causes #differential
Thrombocytopenia 
Work up, differential diagnosis and management.

Satyendra Dhar MD, @DharSaty

#thrombocytopenia #platelets #ITP #DIC
Thrombocytopenia Work up, differential ... diagnosis and management ... thrombocytopenia #platelets