Indications for Transfusion Packed RBCs • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised cardiovascular function • Hgb <10 /dL or hematocrit in a patient with cardiovascular disease, sepsis, or hemoglobinopathy Platelets • Prophylactically for platelet count < 10,000 (adults), or < 50,000 (neonate) • < 30,000 and bleeding or minor bedside procedure • < 50,000 and intraoperative or postoperative bleeding • < 100,000 and bleeding post cardiopulmonary bypass • Do not transfuse platelets in setting of thrombocytopenic thrombotic purpura, heparin-induced thrombocytopenia. Platelet transfusions are unlikely to be useful in idiopathic thrombocytopenic purpura or posttransfusion purpura Fresh frozen plasma • Bleeding in patients with INR > 2 • Bedside procedure and INR > 2 • Prophylaxis (nonbleeding) with INR > 10 • FFP is not indicated for patients with INR <1.5 • Thrombotic thrombocytopenic purpura Cryoprecipitate - Bleeding in the setting of: • Dysfibrinogenemia • Fibrinogen <100 mg/dL • von Willebrand disease #Transfusion #Indications #Thresholds #Management #RBCs #Platelets #FFP
