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diagnosis hematology management syndrome differential leukemia chronic dermatology mds myelodysplastic signs abnormal abscess acute algorithm arteritis atlas beaus classification common
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... Orange or Hep C Clinical ... weeks without infection ... • Neutropenia, anemia ... aplasia • ITP
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... -> AML: Blast crises ... - infiltrates (anemia ... lymphoid organs When Cancer ... Leukemia #Hematology #Oncology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... immunophenotype Clinical ... 5) Symptoms of anemia ... Complications: 1) Infection ... #Leukemia #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Anemia Clinical ... anemia Treatment ... #Anemia #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... cytopenias (usually anemia ... risk-stratification • Risks: infection ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
to impaired B-cell ... to 8 years Clinical ... Granulomatous lymphocytic ... autoimmune hemolytic anemia ... DDX - Other causes
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... petechiae) • Frequent infections ... • Anemia • Aplastic ... • Parvovirus infection ... diagnosis #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... B-LNH), solid cancers ... Drugs, Unknown cause ... Treatment: •
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
History of EBV infection ... Hodgkin Lymphoma - Clinical ... Weight loss • Anemia ... Hodgkin Lymphoma Treatment ... classification #hematology #oncology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Labs: • CD4+ T-cell ... • Leukocyte-lymphocyte ... enzymes ↑ • Mild anemia ... Photophobia • Lymphocytic ... antibody test) Treatment
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