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diagnosis rheumatology classification dermatology signs agglutinin anemia behcet cryofibrinogenemia cryoglobulins dermatologic dermpath erythematosus gpa granulomatosis hemolytic lesions lupus manifestations monoclonal
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... Connective tissue disease ... hemopathies (4%) • Cryoglobulinemia ... lesions #diagnosis #clinical ... pathology #lesions #differential
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Syndrome: • Clinical ... • Autoimmune diseases ... Henoch-Schönlein purpura) • Cutaneous
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... tract, and often causes ... aphthous ulcers, cutaneous ... strong sign of cutaneous ... #rheumatology #
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... gangrenosum • Cutaneous ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... reticularis Differential ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... Diagnosis: • + Clinical ... cryoglobulins • Negative causes ... Antiphospholipid syndrome ... #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Agglutinin Syndrome ... Viral Infection Clinical ... presentation) • Cutaneous ... younger pts) Differential
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... tract, and often causes ... / ANCA + MPO) Cryoglobulinemic ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
) • Cutaneous Lesions ... matter, spinal cord ... (Clinical Dx). ... ) Differential Diagnosis ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... permanent alopecia Differential ... Malignancy (e.g. hematologic ... Clinical Features ... Frank nephritis (hypertension
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