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rheumatology differential classification dermatology cryoglobulins cutaneous dermatologic dermpath granulomatosis lesions manifestations pathology polyangiitis rash relapsing semiology sjogrens types vasculitides
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... (5%): PAN > GPA ... hemopathies (4%) • Cryoglobulinemia ... #semiology #signs ... #lesions #diagnosis
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Cryoglobulinemia ... Syndrome: • Clinical ... • Autoimmune diseases ... - GPA, EGPA, microscopic ... ) #Cryoglobulinemia
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... purpura: strong sign ... Low levels mixed cryoglobulinemia ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
purpura: Strong sign ... MPO > PR3 60/ GPA ... tract, and often causes ... / ANCA + MPO) Cryoglobulinemic ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... ) • Cutaneous vasculitis ... : • 7%, Cryoglobulinemia ... Diagnosis #Management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
the most common clinical ... aneurysms • Cardiac arrhythmia ... /EGPA • RA Diagnosis ... #rheumatology # ... diagnosis #management
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