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rheumatology dermatology differential antinxp2dm classification cryofibrinogenemia cutaneous dermatomyositis dermpath gpa granulomatosis pathology polyangiitis rash semiology sjogrens vasculitides
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
hemopathies (4%) • Cryoglobulinemia ... #dermpath #dermatology ... #semiology #signs ... #lesions #diagnosis ... #clinical #manifestations
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Dermatologic Manifestations ... GPA causes disease ... Rarely dominate the clinical ... purpura • Mixed cryoglobulinemia ... Polyangiitis #GPA #dermatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
, sepsis or cryoglobulinemia ... Manifestations ... • Negative causes ... Calciphylaxis • Cryoglobulinemia ... hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... purpura: strong sign ... Low levels mixed cryoglobulinemia ... Serologies for Cryoglobulins
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... : • 7%, Cryoglobulinemia ... Diagnosis #Management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Auricular skin lesions ... Muscle atrophy may cause ... had more severe disease ... #diagnosis #management ... dermatology
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