5 results
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Clinical Guidelines ... months without treatment ... Hepatitis (AAH) Drug-Induced ... #gastroenterology ... #management #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... deficiency • Reduced ... liver synthesis ... hemorrhage • Disseminated ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Disseminated Intravascular ... organ damage Clinical ... DIC • Severe Liver ... #Coagulation #diagnosis ... #management #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... Disseminated intravascular ... Prolonged #Causes #diagnosis ... #differential #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Sepsis • Drug-induced ... thrombocytopenia • Liver ... Hypofibrinogenemia • ↑ PT ... Treatment: • Corticosteroids ... #Management #Hematology