20 results
Pathogenesis and Pathophysiology of Diabetic Ketoacidosis (DKA)

DKA is a result of an absolute or relative insulin
Pathophysiology of Diabetic ... Ketoacidosis (DKA ... Insulin is the primary ... Pathophysiology #Diabetic ... #Diabetes #Endocrinology
Diabetic Ketoacidosis 
Management Priorities
1. Fluids 
2. Insulin 
3. Potassium 
4. Acidosis 
5. Re-establish oral fluids,
Diabetic Ketoacidosis ... Identification and treatment ... underlying cause #DKA ... #Diabetic #Ketoacidosis ... #Diabetes #Management
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Diabetic Ketoacidosis ... along with IV insulin ... patient has good renal ... pathophysiology #endocrinology ... #diabetes
Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied
produce endogenous insulin ... • Diabetic ketoacidosis ... by complete insulin ... differential #diagnosis #management ... #endocrinology
Hyperuricemia - Differential Diagnosis Algorithm
Primary - Over-production
     • Increased turnover of nucleotides
Primary
Diagnosis Algorithm Primary ... of nucleotides Primary ... Hyperparathyroidism • Diabetic ... acidosis - Renal ... Diagnosis #Algorithm #endocrinology
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
suggests either secondary ... hypokalemia • Renal ... Ureterosigmoidostomy, Diabetic ... Gitelman's syndrome • Primary ... algorithm #causes #nephrology
Classification of Diabetes Insipidus

Central or neurogenic diabetes insipidus:
 - Congenital - Structural malformations affecting the hypothalamus
Classification of Diabetes ... or neurogenic diabetes ... Idiopathic Nephrogenic diabetes ... or dipsogenic diabetes ... #Diabetes #Insipidus
Hyperkalemia Treatment Options
Stabilize cardiac membrane:
 • IV Calcium (peaks 5-10 minutes)
Decrease potassium concentration:
 • IV Fluids
Shift
Hyperkalemia Treatment ... intracellularly: • Insulin ... (if preserved renal ... #Hyperkalemia #management ... #potassium #nephrology
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Increased plasma insulin ... (treatment of diabetic ... thiazide-like diuretics), Primary ... hyperaldosteronism, Secondary ... differential #diagnosis #nephrology
DPP4 Inhibitors - Normal and Renal Dosing

Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
-> Stimulates Insulin ... mechanism helps lower primarily ... #Pharmacology #Management ... #Diabetes #DM2 ... #Endocrinology